The Big Bang Theory

Season 1 Episode 10:

The Cooper-Hofstadter Polarization

Leonard and Sheldon's friendship is put to the test when Leonard wants to present a paper they co-authored at a physics convention, but Sheldon doesn't.
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About The Big Bang Theory:

A woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.