Supernatural

Season 4 Episode 21:

When the Levee Breaks

Sam is becoming more and more inhuman. Dean and Bobby put him in the safe hold until he gets over his addictions. After Sam escapes with help, unknown to him, from Castiel, he finds Ruby and begins to feed once again. Dean begins to truly believe that the old Sam is gone for good.
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About Supernatural:

Two brothers follow their father's footsteps as "hunters" fighting evil supernatural beings of many kinds including monsters, demons, and gods that roam the earth.