Supernatural

Season 4 Episode 17:

It's a Terrible Life

In an alternate reality mysteriously created as if Sam and Dean were never brothers and have never met, Sam and Dean work at a marketing office where they are forced to team up with one another when a series of mysterious suicides point to a ghost haunting the premises.
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About Supernatural:

Two brothers follow their father's footsteps as "hunters" fighting evil supernatural beings of many kinds including monsters, demons, and gods that roam the earth.