Malcolm in the Middle

Season 6 Episode 14:

Ida Loses a Leg

When Grandma Ida visits the family once more, she ends up saving Dewey's life from being run over thus having her leg amputated. Lois forces Francis to take care of his grandma as he's unemployed. Meanwhile Reese and Malcolm decides to go three days without sleeping on the grounds that one of them will be super glued if he fall asleep. Dewey tries to have a leg funeral after feeling bad about what happened to Ida.
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About Malcolm in the Middle:

A gifted young teen tries to survive with his dimwitted, dysfunctional family.