Malcolm in the Middle

Season 5 Episode 13:

Lois' Sister

Lois' younger sister, Susan makes a surprise visit to the Wilkerson house. Immediately, she treats Malcolm, Reese and Dewey like the sons she wishes she had with Hal instead of being single and alone. She also treats Lois as a plague in her life and blames her for being unmarried status. She tells the boys that ever since she caught their mother having sex with their father, she has refused to accept their relationship. However, Susan is plagued with a kidney disease and Lois tries to over hers for her sister.
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About Malcolm in the Middle:

A gifted young teen tries to survive with his dimwitted, dysfunctional family.