Frasier

Season 11 Episode 1:

No Sex Please, We're Skittish

Roz is unsatisfied with her new job, and comes back to KACL, acting as though nothing has changed. Frasier believes her attachment is based on deep attraction to him stemming from their one-night stand. Roz disabuses him of this notion, and they go back to being friends. Recalling that he once donated sperm, Niles returns to the bank to see whether it was ever used, and is told that he suffers from low motility. He tries a variety of weird medical remedies.
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About Frasier:

Dr. Frasier Crane moves back to his hometown of Seattle where he lives with his father and works as a radio psychiatrist.