Family Guy

Season 8 Episode 18:

Quagmire's Dad

Quagmire's dad comes to Quahog and announces that he's undergoing a sex change. And when Brian returns to town after a seminar, he accidentally makes the situation even more awkward.
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About Family Guy:

In a wacky Rhode Island town, a dysfunctional family strive to cope with everyday life as they are thrown from one crazy scenario to another.