Season 1 Episode 142:

Brain Meets Brawn

In the late 1800s, Brain drinks Dr. Jekyll's potion as part of a scheme to take over the British Empire, and then the world.
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About Animaniacs:

The two Warner Brothers Yakko and Wakko and their Warner sister Dot had been (supposedly) created in the 1930's, but their cartoons were too screwy for the general public to handle. The three Warners were locked up in the studio water tower until they escaped in the 90's. There, they run wild, causing chaos everywhere!

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