The Simpsons

Season 20 Episode 17:

The Good, the Sad and the Drugly

Bart gets Milhouse to take the rap for a prank at school, and then blows him off when he falls for a cute 5th grade do-gooder, prompting Milhouse's wrath. Meanwhile, Lisa begins taking 'happy pills' to improve her negative outlook.
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About The Simpsons:

The satiric adventures of a working-class family in the misfit city of Springfield.